Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I/IIa Clinical Trial

15 Jun 2020

Abstract excerpt

PURPOSE: DNA mismatch repair (MMR) deficiency is a hallmark of Lynch syndrome, the most common inherited cancer syndrome. MMR-deficient cancer cells accumulate numerous insertion/deletion mutations at microsatellites. Mutations of coding microsatellites (cMS) lead to the generation of immunogenic frameshift peptide (FSP) neoantigens. As the evolution of MMR-deficient cancers is triggered by mutations inactivating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Immunodeficiency and Autoimmune Disorders
Share to Multiple and Secondary Primary Cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32540851
DOI: 10.1158/1078-0432.ccr-19-3517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I/IIa Clinical TrialPMID 32540851Read ↗

Vaccines for immunoprevention of DNA mismatch repair deficient cancersSemantic proximity Read ↗

Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse ModelSemantic proximity Read ↗

Lynch Syndrome and MSI-H Cancers: From Mechanisms to “Off-The-Shelf” Cancer VaccinesSemantic proximity Read ↗

Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategiesSemantic proximity Read ↗

Advances in immune therapies for the treatment of microsatellite instability‑high/deficient mismatch repair metastatic colorectal cancer (Review)Semantic proximity Read ↗

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolutionSemantic proximity Read ↗

A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite InstabilitySemantic proximity Read ↗

Opportunities for immunotherapy in microsatellite instable colorectal cancer.Semantic proximity Read ↗

Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategiesSemantic proximity Read ↗

RNA Transcription and Splicing Errors as a Source of Cancer Frameshift Neoantigens for VaccinesSemantic proximity Read ↗

Immunotherapy holds the key to cancer treatment and prevention in constitutional mismatch repair deficiency (CMMRD) syndrome.Semantic proximity Read ↗

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor ChallengeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.