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Article

Elevated exopolysaccharide levels in Pseudomonas aeruginosa flagellar mutants have implications for biofilm growth and chronic infections.

PLoS genetics - 1 Jun 2020

Harrison Joe J, Almblad Henrik, Irie Yasuhiko, Wolter Daniel J, Eggleston Heather C, Randall Trevor E, Kitzman Jacob O, Stackhouse Bethany, Emerson Julia C, Mcnamara Sharon, Larsen Tyler J, Shendure Jay, Hoffman Lucas R, Wozniak Daniel J, Parsek Matthew R

Abstract excerpt

Pseudomonas aeruginosa colonizes the airways of cystic fibrosis (CF) patients, causing infections that can last for decades. During the course of these infections, P. aeruginosa undergoes a number of genetic adaptations. One such adaptation is the loss of swimming motility functions. Another involves the formation of the rugose small colony variant (RSCV) phenotype, which is characterized by overproduction of the...

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Identifiers

PMID: 32530919
DOI: 10.1371/journal.pgen.1008848
PMCID: PMC7314104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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