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Article

Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments.

PLoS pathogens - 1 Feb 2018

Pestrak Matthew J, Chaney Sarah B, Eggleston Heather C, Dellos-Nolan Sheri, Dixit Sriteja, Mathew-Steiner Shomita S, Roy Sashwati, Parsek Matthew R, Sen Chandan K, Wozniak Daniel J

Abstract excerpt

Pseudomonas aeruginosa causes devastating infections in immunocompromised individuals. Once established, P. aeruginosa infections become incredibly difficult to treat due to the development of antibiotic tolerant, aggregated communities known as biofilms. A hyper-biofilm forming clinical variant of P. aeruginosa, known as a rugose small-colony variant (RSCV), is frequently isolated from chronic infections and is...

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Identifiers

PMID: 29394295
DOI: 10.1371/journal.ppat.1006842
PMCID: PMC5812653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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