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Article

Pseudomonas aeruginosa biofilm-deficient mutants undergo parallel evolution during chronic infection.

Journal of bacteriology - 18 Jun 2026

Gloag Erin S, Marshall Christopher W, Kubota Nanami, Deaver Stacie E, Deshotel Brennan, Cooper Vaughn S, Wozniak Daniel J

Abstract excerpt

Pseudomonas aeruginosa readily adapts to infection by acquiring stable and heritable mutations. Previously, we discovered that the first adaptations in a porcine wound model were rugose small-colony variants (RSCVs) caused by mutations in the wsp operon. These mutants overproduce Pel and Psl biofilm exopolysaccharides that improve defense against host responses. To identify other mechanisms of host adaptation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42207692
DOI: 10.1128/jb.00520-25
PMCID: PMC13277307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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