Article
BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer.
Cell death & disease - 11 Jun 2020
Pandya Vrajesh, Githaka John Maringa, Patel Namrata, Veldhoen Richard, Hugh Judith, Damaraju Sambasivarao, McMullen Todd, Mackey John, Goping Ing Swie
Abstract excerpt
Apoptosis is fundamental to normal animal development and is the target for many anticancer therapies. Recent studies have explored the consequences of "failed apoptosis" where the apoptotic program is initiated but does not go to completion and does not cause cell death. Nevertheless, this failed apoptosis induces DNA double-strand breaks generating mutations that facilitate tumorigenesis. Whether failed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.