Article
A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma.
Cell - 23 Jul 2020
Liu Jinping, Tang Wei, Budhu Anuradha, Forgues Marshonna, Hernandez Maria O, Candia Julián, Kim Yujin, Bowman Elise D, Ambs Stefan, Zhao Yongmei, Tran Bao, Wu Xiaolin, Koh Christopher, Surana Pallavi, Liang T Jake, Guarnera Maria, Mann Dean, Rajaure Manoj, Greten Tim F, Wang Zhanwei, Yu Herbert, Wang Xin Wei
Abstract excerpt
Hepatocellular carcinoma (HCC) is an aggressive malignancy with its global incidence and mortality rate continuing to rise, although early detection and surveillance are suboptimal. We performed serological profiling of the viral infection history in 899 individuals from an NCI-UMD case-control study using a synthetic human virome, VirScan. We developed a viral exposure signature and validated the results in a...
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