Phosphodiesterase 3A and Arterial Hypertension.

doi:10.1161/CIRCULATIONAHA.119.043061

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Article

Phosphodiesterase 3A and Arterial Hypertension.

Circulation - 14 Jul 2020

Ercu Maria, Markó Lajos, Schächterle Carolin, Tsvetkov Dmitry, Cui Yingqiu, Maghsodi Sara, Bartolomaeus Theda U P, Maass Philipp G, Zühlke Kerstin, Gregersen Nerine, Hübner Norbert, Hodge Russell, Mühl Astrid, Pohl Bärbel, Illas Rosana Molé, Geelhaar Andrea, Walter Stephan, Napieczynska Hanna, Schelenz Stefanie, Taube Martin, Heuser Arnd, Anistan Yoland-Marie, Qadri Fatimunnisa, Todiras Mihail, Plehm Ralph, Popova Elena, Langanki Reika, Eichhorst Jenny, Lehmann Martin, Wiesner Burkhard, Russwurm Michael, Forslund Sofia K, Kamer Ilona, Müller Dominik N, Gollasch Maik, Aydin Atakan, Bähring Sylvia, Bader Michael, Luft Friedrich C, Klussmann Enno

Abstract excerpt

BACKGROUND: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt-resistant essential hypertension and causes death by stroke before 50 years of age. We recently implicated the gene encoding phosphodiesterase 3A (PDE3A); however, in vivo modeling of the genetic defect and thus showing an involvement of mutant...

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PMID: 32524868
DOI: 10.1161/CIRCULATIONAHA.119.043061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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