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Article

Personal Genetic-Hypertension Odyssey From Phenotypes to Genotypes and Targets.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2024

Luft Friedrich C

Abstract excerpt

Hypertension requires increased systemic vascular resistance. Thus far, Mendelian hypertension-related genes are related to salt retention, an indirect regulatory effect. With the identification of mutated, overactive, PDE3A (phosphodiesterase 3A), we have uncovered a more direct vasoconstrictive mechanism. The autosomal-dominant syndrome features another specific phenotype, brachydactyly type E. Hypertension and...

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Identifiers

PMID: 39355912
DOI: 10.1161/HYPERTENSIONAHA.124.21714

Genes

PDE3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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