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Article

Hypertension linked to PDE3A activation.

Nature genetics - 1 Jun 2015

Houslay Miles

Abstract excerpt

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

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Share to Cyclic Nucleotide Phosphodiesterases, Type 3
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Source

Identifiers

PMID: 26018892
DOI: 10.1038/ng.3316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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