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Article

Long non-coding RNA XIST contributes to osteoarthritis progression via miR-149-5p/DNMT3A axis

7 Jun 2020

Abstract excerpt

Long non-coding RNAs (lncRNAs) are largely involved in the development of osteoarthritis (OA), a chronic and degenerative joint disease. The objective of this paper is to research the functional role and molecular mechanism of lncRNA X inactive specific transcript (XIST) in OA. The levels of XIST, microRNA-149-5p (miR-149-5p), and DNA methyltransferase 3A (DNMT3A) were measured. Cell viability and apoptosis rate...

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PMID: 32521454
DOI: 10.1016/j.biopha.2020.110349

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