Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture

1 Dec 2019

Abstract excerpt

BACKGROUND: Hypermethylation of gene promoters has been regarded as an epigenetic regulator for gene inactivation in the development of several diseases. In the current study, we aimed to explore how long noncoding RNA X-inactive specific transcript (lncRNA XIST) function in collagen degradation in chondrocytes of osteoarthritis (OA) after tibial plateau fracture by regulating tissue inhibitor of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31815654
DOI: 10.1186/s13075-019-2033-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracturePMID 31815654Read ↗

Long non-coding RNA XIST contributes to osteoarthritis progression via miR-149-5p/DNMT3A axisSemantic proximity Read ↗

Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthritisSemantic proximity Read ↗

A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathwaySemantic proximity Read ↗

LncRNA HOTAIR-mediated Wnt/β-catenin network modeling to predict and validate therapeutic targets for cartilage damageSemantic proximity Read ↗

New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritisSemantic proximity Read ↗

A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathwaySemantic proximity Read ↗

LncRNA XIST: A Breakthrough in Inflammation-related DiseasesSemantic proximity Read ↗

The emerging role of lncRNAs in chondrocytes from osteoarthritis patientsSemantic proximity Read ↗

Epigenetic Biomarkers in Temporomandibular Joint Osteoarthritis: An Emerging Target in TreatmentSemantic proximity Read ↗

Long Non-coding RNA PVT1 Promotes Chondrocyte Extracellular Matrix Degradation by Acting as a Sponge for miR-140 in IL-1β-stimulated ChondrocytesSemantic proximity Read ↗

The role of lncRNA XIST/miR-211 axis in modulating the proliferation and apoptosis of osteoarthritis chondrocytes through CXCR4 and MAPK signalingSemantic proximity Read ↗

miR‐142‐5p protects against osteoarthritis through competing with lncRNA XISTSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.