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Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure

10 Jun 2020

Abstract excerpt

We conducted an epigenome-wide association study meta-analysis on blood pressure (BP) in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA methylation data from peripheral leukocytes were obtained using the Infinium Human Methylation 450k BeadChip. The epigenome-wide association study meta-analysis identified 39 BP-related CpG sites with P <1×10 −5 . In silico replication in the...

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PMID: 32520614
DOI: 10.1161/hypertensionaha.120.14973

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