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Article

Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium.

Nature communications - 8 Jun 2020

Aparicio David, Scheffer Margot P, Marcos-Silva Marina, Vizarraga David, Sprankel Lasse, Ratera Mercè, Weber Miriam S, Seybert Anja, Torres-Puig Sergi, Gonzalez-Gonzalez Luis, Reitz Julian, Querol Enrique, Piñol Jaume, Pich Oscar Q, Fita Ignacio, Frangakis Achilleas S

Abstract excerpt

Mycoplasma genitalium is a human pathogen adhering to host target epithelial cells and causing urethritis, cervicitis and pelvic inflammatory disease. Essential for infectivity is a transmembrane adhesion complex called Nap comprising proteins P110 and P140. Here we report the crystal structure of P140 both alone and in complex with the N-terminal domain of P110. By cryo-electron microscopy (cryo-EM) and...

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Identifiers

PMID: 32513917
DOI: 10.1038/s41467-020-16511-2
PMCID: PMC7280502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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