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Article

Next-generation sequencing in residual liquid-based cytology specimens for cancer genome analysis.

Diagnostic cytopathology - 1 Nov 2020

Yamaguchi Tomomi, Akahane Toshiaki, Harada Ohi, Kato Yasutaka, Aimono Eriko, Takei Hidehiro, Tasaki Takashi, Noguchi Hirotsugu, Nishihara Hiroshi, Kamata Hajime, Tanimoto Akihide

Abstract excerpt

BACKGROUND: Cancer genome profiling of cytology specimens using next-generation sequencing (NGS) requires adequate and good-quality DNA. Genomic examination of cytology samples was conventionally performed on cell block (CB) or smear specimens than on residual liquid-based cytology (LBC) specimens, which are high-quality DNA sources even after long-term storage. METHODS: We estimated tumor fractions of 37...

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PMID: 32511899
DOI: 10.1002/dc.24511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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