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Article

Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers.

Cancer letters - 28 Jan 2014

Fukushige Shinichi, Horii Akira

Abstract excerpt

The prognosis of pancreatic cancer is extremely poor, mainly because of its aggressive biological behavior and late onset of symptoms for clinical diagnosis; these impose limitations on therapeutic intervention. Deeper genomic sequencing analyses of pancreatic cancers revealed 12 core pathways and a long duration, nearly 20 years from initiation to distant metastases. This evidence will offer a broader aspect and...

Topics

Animals
Biomarkers, Tumor
DNA Methylation
Early Detection of Cancer
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Genetic Testing
Histones
Humans
MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Repeats

Pancreatic Neoplasms

Phenotype

Predictive Value of Tests

Prognosis

Source

Identifiers

PMID: 22450751
DOI: 10.1016/j.canlet.2012.03.022

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