Article
BMP-2 Variants in Breast Epithelial to Mesenchymal Transition and Microcalcifications Origin.
Cells - 2 Jun 2020
Scimeca Manuel, Giocondo Raffaella, Montanaro Manuela, Granaglia Annarita, Bonfiglio Rita, Tancredi Virginia, Mauriello Alessandro, Urbano Nicoletta, Schillaci Orazio, Bonanno Elena
Abstract excerpt
This study aims to investigate the possible different roles of the BMP-2 variants, cytoplasmic and nuclear variant, in both epithelial to mesenchymal transition and in microcalcifications origin in human breast cancers. To this end, the in situ expression of cytoplasmic and nuclear BMP-2 was associated with the expression of the main epithelial to mesenchymal transition biomarkers (e-cadherin and vimentin) and...
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