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Article

Characterization of the catalytic center of the Ebola virus L polymerase

9 Oct 2017

Abstract excerpt

BACKGROUND: Ebola virus (EBOV) causes a severe hemorrhagic fever in humans and non-human primates. While no licensed therapeutics are available, recently there has been tremendous progress in developing antivirals. Targeting the ribonucleoprotein complex (RNP) proteins, which facilitate genome replication and transcription, and particularly the polymerase L, is a promising antiviral approach since these processes...

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PMID: 28991917
DOI: 10.1371/journal.pntd.0005996

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