Article
Association of gBRCA1/2 mutation locations with ovarian cancer risk in Japanese patients from the CHARLOTTE study.
Cancer science - 1 Sept 2020
Yoshihara Kosuke, Enomoto Takayuki, Aoki Daisuke, Watanabe Yoh, Kigawa Junzo, Takeshima Nobuhiro, Inomata Hyoe, Hattori Kana, Jinushi Masahisa, Tsuda Hitoshi, Sugiyama Toru
Abstract excerpt
Whether germline (g) breast cancer susceptibility gene (BRCA) mutations are located within or outside the ovarian cancer cluster region (OCCR) (1380-4062 bp for gBRCA1, and between 3249-5681 bp and 6645-7471 bp for gBRCA2) may influence risk variations for ovarian cancers. This ad hoc analysis of the CHARLOTTE epidemiological study in Japan assessed the distribution of gBRCA1/2 mutations in patients with newly...
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