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Article

Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors.

Antimicrobial agents and chemotherapy - 1 Nov 2014

Schuster Sabine, Kohler Samay, Buck Annika, Dambacher Christine, König Armin, Bohnert Jürgen A, Kern Winfried V

Abstract excerpt

Efflux is an important mechanism of bacterial multidrug resistance (MDR), and the inhibition of MDR pumps by efflux pump inhibitors (EPIs) could be a promising strategy to overcome MDR. 1-(1-Naphthylmethyl)-piperazine (NMP) and phenylalanine-arginine-β-naphthylamide (PAβN) are model EPIs with activity in various Gram-negative bacteria expressing AcrB, the major efflux pump of Escherichia coli, or similar...

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Identifiers

PMID: 25182653
DOI: 10.1128/AAC.03775-14
PMCID: PMC4249408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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