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Article

Fitness Cost and Compensatory Evolution in Levofloxacin-Resistant Mycobacterium aurum.

Antimicrobial agents and chemotherapy - 22 Jul 2020

Pi Rui, Liu Qingyun, Takiff Howard E, Gao Qian

Abstract excerpt

We isolated spontaneous levofloxacin-resistant strains of Mycobacterium aurum to study the fitness cost and compensatory evolution of fluoroquinolone resistance in mycobacteria. Five of six mutant strains with substantial growth defects showed restored fitness after being serially passaged for 18 growth cycles, along with increased cellular ATP level. Whole-genome sequencing identified putative compensatory...

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Identifiers

PMID: 32482677
DOI: 10.1128/AAC.00224-20
PMCID: PMC7526816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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