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Article

Apoptotic Death of Cancer Stem Cells for Cancer Therapy

12 May 2014

Abstract excerpt

Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective CSC apoptotic...

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PMID: 24823879
DOI: 10.3390/ijms15058335

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