Article
The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer.
British journal of cancer - 1 Aug 2020
Ray Anita L, Nofchissey Robert A, Khan Maaz A, Reidy Megan A, Lerner Megan R, Wu Xiangyan, Guo Shaoxuan, Hill Spencer L, Weygant Nathaniel, Adams Sarah F, Castillo Eliseo F, Berry William L, Stout Michael B, Morris Katherine T
Abstract excerpt
BACKGROUND: Women with colorectal cancer (CRC) have a significant survival advantage over men. Sex influences on the tumour microenvironment (TME) are not well characterised, despite the importance of immune response in CRC. We hypothesised that sex-divergent immune responses could contribute to survival. METHODS: Using a murine model of metastatic CRC, we examined T cells, macrophages, and cytokines locally and...
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