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Article

Differential immune signatures in the tumor microenvironment are associated with colon cancer racial disparities.

Cancer medicine - 1 Mar 2021

Curran Thomas, Sun Zequn, Gerry Brielle, Findlay Victoria J, Wallace Kristin, Li Zihai, Paulos Chrystal, Ford Marvella, Rubinstein Mark P, Chung Dongjun, Camp E Ramsay

Abstract excerpt

BACKGROUND: Disparities in colon cancer (CC) outcomes may be due to a more aggressive phenotype in African American patients in the setting of a decreased tumor immunity, though the precise mechanism for this result has not been well elucidated. To explore the molecular factors underlying CC disparities, we compared the immunogenomic signatures of CC from African American and European American patients. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33560598
DOI: 10.1002/cam4.3753
PMCID: PMC7940243

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