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Non-small cell lung carcinomas with CTNNB1 (beta-catenin) mutations: A clinicopathological study of 26 cases.

Annals of diagnostic pathology - 1 Jun 2020

Thomas de Montpréville Vincent, Lacroix Ludovic, Rouleau Etienne, Mamodaly Maria, Leclerc Julie, Tutuianu Loredana, Planchard David, Boulate David, Mercier Olaf, Besse Benjamin, Fadel Élie, Ghigna Maria-Rosa

Abstract excerpt

Beta-catenin, encoded by the CTNNB1 gene, plays an important role in cell proliferation. Mutations of CTNNB1 are oncogenic in several tumor types and are often associated with a nuclear abnormal expression. However, such mutations have only rarely been reported in non-small cell lung carcinomas and their clinical signification is not well described. Our study was conducted on 26 CTNNB1-mutated non-small cell lung...

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PMID: 32442860
DOI: 10.1016/j.anndiagpath.2020.151522

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