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Article

Complementation studies with human ClpP in Bacillus subtilis.

Biochimica et biophysica acta. Molecular cell research - 1 Sept 2020

Dittmar Denise, Reder Alexander, Schlüter Rabea, Riedel Katharina, Hecker Michael, Gerth Ulf

Abstract excerpt

ATP-dependent intracellular proteolysis is essential for all living organisms. ClpP, the proteolytic subunit of the ATP-dependent Clp proteases, shares 56% protein identity between B. subtilis and man. The aim of this study was to verify, whether human ClpP (HClpP) is able to substitute the bacterial pendant, BClpP, irrespectively of the huge evolutionary distance. For this reason hclpP was expressed from the...

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Identifiers

PMID: 32442436
DOI: 10.1016/j.bbamcr.2020.118744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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