Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain.

Nature communications - 1 Jan 2013

Fischer Fabian, Weil Andrea, Hamann Andrea, Osiewacz Heinz D

Abstract excerpt

Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix. Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Computational Biology
Share to Endopeptidase Clp

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Genetic Complementation Test

Share to Mitochondrial Proteins

Share to Protease La

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 23360988
DOI: 10.1038/ncomms2397
PMCID: PMC3562451

Genes

CLPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain.PMID 23360988Read ↗

Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan.Semantic proximity Read ↗

Loss of conserved mitochondrial CLPP and its functions lead to different phenotypes in plants and other organisms.Semantic proximity Read ↗

Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain.Semantic proximity Read ↗

Perrault syndrome type 3 caused by diverse molecular defects in CLPP.Semantic proximity Read ↗

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX With Its Interactors at the Nucleoid and RNA GranuleSemantic proximity Read ↗

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.Semantic proximity Read ↗

The Bacterial ClpXP-ClpB Family is Enriched with RNA-Binding Protein ComplexesSemantic proximity Read ↗

Knockout Mouse Studies Show Mitochondrial CLPP Peptidase and CLPX Unfoldase to Act in Matrix Condensates Near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme ProductionSemantic proximity Read ↗

Complementation studies with human ClpP in Bacillus subtilis.Semantic proximity Read ↗

Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis.Semantic proximity Read ↗

Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX.Semantic proximity Read ↗

Age-Related Cellular Copper Dynamics in the Fungal Ageing Model Podospora anserina and in Ageing Human FibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.