Article
The retinoblastoma paradigm revisited.
Medical science monitor : international medical journal of experimental and clinical research - 1 Dec 2008
Mastrangelo Domenico, De Francesco Sonia, Di Leonardo Aldo, Lentini Laura, Hadjistilianou Theodora
Abstract excerpt
BACKGROUND: Retinoblastoma (Rb) is the most common primary malignant intraocular tumour in childhood. The "two hit" theory, formulated by Knudson in 1971 to explain the variegated clinical expression of the disease, led to the discovery of the so called tumour suppressor genes and the identification of the Rb1 as the prototype of such genes. Mutations of the Rb1 gene are now commonly believed to be the "cause"...
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