Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants.

Immunity - 19 May 2020

Korem Kohanim Yael, Tendler Avichai, Mayo Avi, Friedman Nir, Alon Uri

Abstract excerpt

Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues maintain mass through feedback loops that balance cell proliferation and removal according to hormone-driven regulatory signals. We hypothesized the existence of a dedicated mechanism that detects and removes mutant cells that missense the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Cell Proliferation
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endocrine System

Share to Immunologic Surveillance

Share to Mutation

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 32433950
DOI: 10.1016/j.immuni.2020.04.022
PMCID: PMC7237888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants.PMID 32433950Read ↗

Autoimmune endocrine diseases.Semantic proximity Read ↗

B cell lymphoproliferation and organ-directed self-recognition to explain autoimmunity: back to the past.Semantic proximity Read ↗

Tipping the balance in autoimmune disease.Semantic proximity Read ↗

Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunitySemantic proximity Read ↗

Why is the thyroid so prone to autoimmune disease?Semantic proximity Read ↗

Chronic autoimmune disease caused by somatic mutation to T-lymphocyte regulatory receptors.Semantic proximity Read ↗

Insights Obtained from the Nontumorous Glandular Tissue in Patients with Endocrine Tumors.Semantic proximity Read ↗

Thymic B Cells as a New Player in the Type 1 Diabetes Response.Semantic proximity Read ↗

Ecoimmunity: immune tolerance by symmetric co-evolution.Semantic proximity Read ↗

Extrathymic mechanisms of T cell tolerance: lessons from autoimmune gastritis.Semantic proximity Read ↗

Genetic lesions in T‐cell tolerance and thresholds for autoimmunitySemantic proximity Read ↗

"Ioning" out thyroid autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.