Article
The role of minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse.
Leukemia - 1 Jun 2012
Bachas C, Schuurhuis G J, Assaraf Y G, Kwidama Z J, Kelder A, Wouters F, Snel A N, Kaspers G J L, Cloos J
Abstract excerpt
The majority of pediatric and younger adult (<60 years) AML patients achieve complete remission. However, 30-40% of patients relapse and display a dismal outcome. Recently we described a frequent instability of type I/II mutations between diagnosis and relapse. Here, we explored the hypothesis that these mutational shifts originate from clonal selection during treatment/disease progression. Subfractions of blasts...
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