Article
Differential antigen expression and aberrant signaling via PI3/AKT, MAP/ERK, JAK/STAT, and Wnt/β catenin pathways in Lin-/CD38-/CD34+ cells in acute myeloid leukemia.
European journal of haematology - 1 Mar 2016
Garg Swati, Shanmukhaiah Chandrakala, Marathe Supreet, Mishra Prashant, Babu Rao Vunditi, Ghosh Kanjaksha, Madkaikar Manisha
Abstract excerpt
Acute myeloid leukemia is often called as stem cell disease that presents with treatment failure and poor disease outcome. Leukemic stem cells in acute myeloid leukemia (AML) are enriched in Lineage-/CD38-/CD34+ compartment of CD34-positive AML. Many markers important for stem cell biology have been reported for their association with leukemic stem cell population, but what remains clinically most important is a...
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