Article
Variations in maternal vitamin A intake modifies phenotypes in a mouse model of 22q11.2 deletion syndrome.
Birth defects research - 1 Oct 2020
Yitsege Gelila, Stokes Bethany A, Sabatino Julia A, Sugrue Kelsey F, Banyai Gabor, Paronett Elizabeth M, Karpinski Beverly A, Maynard Thomas M, LaMantia Anthony-S, Zohn Irene E
Abstract excerpt
BACKGROUND: Vitamin A regulates patterning of the pharyngeal arches, cranial nerves, and hindbrain that are essential for feeding and swallowing. In the LgDel mouse model of 22q11.2 deletion syndrome (22q11DS), morphogenesis of multiple structures involved in feeding and swallowing are dysmorphic. We asked whether changes in maternal dietary Vitamin A intake can modify cranial nerve, hindbrain and pharyngeal arch...
Topics
- Animals
- Deglutition
- DiGeorge Syndrome
- Disease Models, Animal
- Mice
- Phenotype
- Vitamin A