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Article

Reduced maternal vitamin A status increases the incidence of normal aortic arch variants

1 Jul 2019

Abstract excerpt

While common in the general population, the developmental origins of "normal" anatomic variants of the aortic arch remain unknown. Aortic arch development begins with the establishment of the second heart field (SHF) that contributes to the pharyngeal arch arteries (PAAs). The PAAs remodel during subsequent development to form the mature aortic arch and arch vessels. Retinoic acid signaling involving the...

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PMID: 31299141
DOI: 10.1002/dvg.23326

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