Article
Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis.
Developmental cell - 18 May 2020
Bürgi Jérôme, Abrami Laurence, Castanon Irinka, Abriata Luciano Andres, Kunz Beatrice, Yan Shixu Emili, Lera Manuel, Unger Sheila, Superti-Furga Andrea, Peraro Matteo Dal, Gaitan Marcos Gonzalez, van der Goot Francoise Gisou
Abstract excerpt
Capillary morphogenesis gene 2 (CMG2/ANTXR2) is a cell surface receptor for both collagen VI and anthrax toxin. Biallelic loss-of-function mutations in CMG2 lead to a severe condition, hyaline fibromatosis syndrome (HFS). We have here dissected a network of dynamic interactions between CMG2 and various actin interactors and regulators, describing a different behavior from other extracellular matrix receptors....
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