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An NGS-based HLA haplotype analysis and population comparison between two cities in Rio de Janeiro, Brazil.

HLA - 1 Sept 2020

Vianna Romulo, Secco Danielle, Hanhoerderster Leonardo, Motta Juliana, Cardoso Juliana, Porto Luís Cristóvão

Abstract excerpt

HLA genes can exhibit extensive variations in frequency, especially in highly admixed populations, such as that of Brazil. In this study, we demonstrated NGS-based HLA typing in our laboratory using an Illumina HiSeq 2500 sequencing platform and downstream analysis. We herein describe and compare the allele and haplotype frequencies of the populations in Barra Mansa (BM) and Rio de Janeiro (RJ), using the...

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PMID: 32424903
DOI: 10.1111/tan.13940

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