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Article

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2020

Fang Zhenhao, Lee Ki-Young, Huo Ku-Geng, Gasmi-Seabrook Geneviève, Zheng Le, Moghal Nadeem, Tsao Ming-Sound, Ikura Mitsuhiko, Marshall Christopher B

Abstract excerpt

Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is limited to isolated domains. The RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF engage KRAS and the plasma membrane, unleashing the kinase domain from autoinhibition. Due to experimental challenges, structural insight into this tripartite...

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Identifiers

PMID: 32414921
DOI: 10.1073/pnas.1914076117
PMCID: PMC7275734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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