Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits.

doi:10.1161/CIRCHEARTFAILURE.119.006749

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Article

Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits.

Circulation. Heart failure - 1 May 2020

Nayor Matthew, Short Meghan I, Rasheed Humaira, Lin Honghuang, Jonasson Christian, Yang Qiong, Hveem Kristian, Felix Janine F, Morrison Alanna C, Wild Philipp S, Morley Michael P, Cappola Thomas P, Benson Mark D, Ngo Debby, Sinha Sumita, Keyes Michelle J, Shen Dongxiao, Wang Thomas J, Larson Martin G, Brumpton Ben M, Gerszten Robert E, Omland Torbjørn, Vasan Ramachandran S

Abstract excerpt

BACKGROUND: We used a large-scale, high-throughput DNA aptamer-based discovery proteomic platform to identify circulating biomarkers of cardiac remodeling and incident heart failure (HF) in community-dwelling individuals. METHODS: We evaluated 1895 FHS (Framingham Heart Study) participants (age 55±10 years, 54% women) who underwent proteomic profiling and echocardiography. Plasma levels of 1305 proteins were...

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PMID: 32408813
DOI: 10.1161/CIRCHEARTFAILURE.119.006749
PMCID: PMC7236427

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