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Article

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.

Circulation - 26 Jul 2016

Ngo Debby, Sinha Sumita, Shen Dongxiao, Kuhn Eric W, Keyes Michelle J, Shi Xu, Benson Mark D, O'Sullivan John F, Keshishian Hasmik, Farrell Laurie A, Fifer Michael A, Vasan Ramachandran S, Sabatine Marc S, Larson Martin G, Carr Steven A, Wang Thomas J, Gerszten Robert E

Abstract excerpt

BACKGROUND: Single-stranded DNA aptamers are oligonucleotides of ≈50 base pairs in length selected for their ability to bind proteins with high specificity and affinity. Emerging DNA aptamer-based technologies may address limitations of existing proteomic techniques, including low sample throughput, which have hindered proteomic analyses of large cohorts. METHODS: To identify early biomarkers of myocardial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cardiomyopathy, Hypertrophic

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Identifiers

PMID: 27444932
DOI: 10.1161/CIRCULATIONAHA.116.021803
PMCID: PMC4963294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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