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Article

Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B.

Investigative ophthalmology & visual science - 11 May 2020

Pilotti Camilla, Greenwood John, Moss Stephen E

Abstract excerpt

Purpose: The 32W and 32Q variants of complement factor B (CFB) are associated with reduced risk of developing neovascular age-related macular degeneration (AMD) compared with the common 32R allele. The objective of this study was to determine if the most protective R32Q variant affects the neovascular process in a manner consistent with the reported reduced disease association. Methods: The 32R, 32W, and 32Q...

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Share to Recombinant Proteins
Share to Choroidal Neovascularization
Share to Complement Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement C3

Share to Complement Factor B

Share to Macrophages

Share to Macular Degeneration

Share to Vascular Endothelial Growth Factor A

Source

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Identifiers

PMID: 32407521
DOI: 10.1167/iovs.61.5.19
PMCID: PMC7405614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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