Article

Improved Arterial Stiffness and Bone Mineral Density in Hutchinson–Gilford Progeria Treated with Bone Marrow-Derived Mesenchymal Stem Cells: A Case Study and Literature Review

2025-02-18

Abstract excerpt

<h4>Background: </h4> /Objectives: Hutchinson‒Gilford progeria syndrome (HGPS) is a rare ge-netic disorder caused by LMNA gene mutations, leading to the accumulation of farne-sylated progerin. It is characterized by severe growth failure, premature aging, rapid progression of atherosclerosis and cardiovascular- related early disease. Lonafarnib, a farnesyltransferase inhibitor, extends life expectancy in HGPS, but...

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Literature Corpus work: 35ac8425-a29b-56dc-8d10-9d0f5420544b
DOI: 10.20944/preprints202502.1434.v1

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