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Clonal tumor mutations in homologous recombination genes predict favorable clinical outcome in ovarian cancer treated with platinum-based chemotherapy.

Gynecologic oncology - 1 Jul 2020

Luo Shangyi, Zhang Yajing, Yang Yiran, Zhu Shiwei, Liu Wei, Zhu Jiali, Liang Xin, Jiang Zedong, Sun Shangqin, Hou Xiaobo, Xiao Yun, Li Xia

Abstract excerpt

OBJECTIVE: Platinum-based chemotherapy remains the first-line treatment for ovarian carcinoma by inducing DNA damage. The therapeutic impact of clonal and subclonal somatic mutations in DNA damage repair (DDR) pathways remains unexplored. METHODS: We performed an integrated analysis to infer the clonality of somatic deleterious mutations in 385 ovarian carcinomas treated with platinum-based chemotherapy. The...

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PMID: 32402633
DOI: 10.1016/j.ygyno.2020.04.695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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