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Article

Paclitaxel is necessary for improved survival in epithelial ovarian cancers with homologous recombination gene mutations.

Oncotarget - 26 Jul 2016

Jean Stephanie, Li Jiaqi, Katsaros Dionyssios, Wubbenhorst Bradley, Maxwell Kara N, Fishbein Lauren, McLane Michael W, Benedetto Chiara, Canuto Emilie Marion, Mitra Nandita, Zhang Lin, Nathanson Katherine L, Tanyi Janos L

Abstract excerpt

PURPOSE: To investigate the impact of somatic mutations in homologous recombination (HR) genes on the chemotherapeutic response and survival of patients with epithelial ovarian cancer (EOC). EXPERIMENTAL DESIGN: We performed targeted massively parallel sequencing of tumor DNA from 158 patients with EOC. We associated adjuvant chemotherapy and clinical outcome with mutations in selected genes, focusing on those...

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Share to Carcinoma, Ovarian Epithelial
Share to Chemotherapy, Adjuvant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclophosphamide

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Share to Neoplasms, Glandular and Epithelial

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Source

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Identifiers

PMID: 27191893
DOI: 10.18632/oncotarget.9373
PMCID: PMC5217039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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