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Article

Association of early-onset Alzheimer's disease with germline-generated high affinity self-antigen load.

Translational psychiatry - 12 May 2020

Huang Poyin, Yang Yuan-Han, Chang Ya-Hsuan, Chang Shu-Ling, Chou Mei-Chuan, Lai Chiou-Lian, Liu Ching-Kuan, Chen Hsuan-Yu

Abstract excerpt

Self-antigen presentation outside the central nervous system has crucial role regarding self-proteins tolerance and autoimmunity, leading to neuroinflammation. Self-antigen with strong-binding affinity is considered to be pathogenic. We aim to investigate whether strong-binding affinity self-antigen load is associated with early/late-onset Alzheimer's disease (AD). A total of 54 AD samples (22 early-onset, 32...

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Identifiers

PMID: 32398703
DOI: 10.1038/s41398-020-0826-6
PMCID: PMC7217838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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