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Alzheimer Disease Pathogenesis: The Role of Autoimmunity

15 Sept 2020

Abstract excerpt

BACKGROUND: In addition to deposits of amyloid β (Aβ) plaques and neurofibrillary tangles, growing evidence demonstrates that complex and multifaceted biological processes can arise during Alzheimer disease (AD) pathogenesis. The recent failures of clinical trials based on the amyloid hypothesis and the presence of Aβ plaques in cognitively healthy elderly persons without AD point toward a need to explore novel...

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PMID: 33241314
DOI: 10.1093/jalm/jfaa171

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