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Article

Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death.

mBio - 12 May 2020

Thak Eun Jung, Lee Su-Bin, Xu-Vanpala Shengjie, Lee Dong-Jik, Chung Seung-Yeon, Bahn Yong-Sun, Oh Doo-Byoung, Shinohara Mari L, Kang Hyun Ah

Abstract excerpt

Cryptococcus neoformans is a human-pathogenic fungal pathogen that causes life-threatening meningoencephalitis in immunocompromised individuals. To investigate the roles of N-glycan core structure in cryptococcal pathogenicity, we constructed mutant strains of C. neoformans with defects in the assembly of lipid-linked N-glycans in the luminal side of the endoplasmic reticulum (ER). Deletion of ALG3 (alg3Δ), which...

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Identifiers

PMID: 32398313
DOI: 10.1128/mBio.00711-20
PMCID: PMC7218283

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