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Article

Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus.

PLoS pathogens - 1 Oct 2011

Snyder Christopher M, Cho Kathy S, Bonnett Elizabeth L, Allan Jane E, Hill Ann B

Abstract excerpt

Cytomegalovirus (CMV) is a β-herpesvirus that establishes a lifelong latent or persistent infection. A hallmark of chronic CMV infection is the lifelong persistence of large numbers of virus-specific CD8+ effector/effector memory T cells, a phenomenon called "memory inflation". How the virus continuously stimulates these T cells without being eradicated remains an enigma. The prevailing view is that CMV...

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Identifiers

PMID: 21998590
DOI: 10.1371/journal.ppat.1002295
PMCID: PMC3188546

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