Article
Expression of GNAS, TP53, and PTEN Improves the Patient Prognostication in Sonic Hedgehog (SHH) Medulloblastoma Subgroup.
The Journal of molecular diagnostics : JMD - 1 Jul 2020
da Silva Luciane S, Mançano Bruna M, de Paula Flávia E, Dos Reis Mariana B, de Almeida Gisele C, Matsushita Marcus, Junior Carlos A, Evangelista Adriane F, Saggioro Fabiano, Serafini Luciano N, Stavale João N, Malheiros Suzana M F, Lima Matheus, Hajj Glaucia N M, de Lima Marcos A, Taylor Michael D, Leal Letícia F, Reis Rui M
Abstract excerpt
Medulloblastoma (MB) is the most common malignant brain tumor in children. It is currently classified in four main molecular subgroups with different clinical outcomes: sonic hedgehog, wingless, group 3, and group 4 (MBSHH, MBWNT, MBGRP3, or MBGRP4). Presently, a 22-gene expression panel has been efficiently applied for molecular subgrouping using nCounter technology. In this study, formalin-fixed,...
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