Article
HPOLabeler: improving prediction of human protein-phenotype associations by learning to rank.
Bioinformatics (Oxford, England) - 15 Aug 2020
Liu Lizhi, Huang Xiaodi, Mamitsuka Hiroshi, Zhu Shanfeng
Abstract excerpt
MOTIVATION: Annotating human proteins by abnormal phenotypes has become an important topic. Human Phenotype Ontology (HPO) is a standardized vocabulary of phenotypic abnormalities encountered in human diseases. As of November 2019, only <4000 proteins have been annotated with HPO. Thus, a computational approach for accurately predicting protein-HPO associations would be important, whereas no methods have...
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