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Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments

21 May 2020

Abstract excerpt

Cardiovascular diseases have become the leading cause of human death. Aging is an independent risk factor for cardiovascular diseases. Cardiac aging is associated with maladaptation of cellular metabolism, dysfunction (or senescence) of cardiomyocytes, a decrease in angiogenesis, and an increase in tissue scarring (fibrosis). These events eventually lead to cardiac remodeling and failure. Senescent cardiomyocytes...

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PMID: 32508749
DOI: 10.3389/fendo.2020.00280

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