Article
Greater utility of molecular subtype rather than epithelial-to-mesenchymal transition (EMT) markers for prognosis in high-risk non-muscle-invasive (HGT1) bladder cancer.
The journal of pathology. Clinical research - 1 Oct 2020
Ottley Edward C, Pell Robert, Brazier Benedict, Hollidge Julianne, Kartsonaki Christiana, Browning Lisa, O'Neill Eric, Kiltie Anne E
Abstract excerpt
Approximately 75% of bladder cancers are non-muscle invasive (NMIBC). Of these, up to 53% of cases progress to life-threatening muscle-invasive bladder cancer (MIBC). Patients with high-grade stage T1 (HGT1) NMIBC frequently undergo radical cystectomy (RC), although this represents overtreatment for many. Identification of progressors versus non-progressors could spare unnecessary treatment. Recent studies have...
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