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Article

Sex-specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia-susceptible mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2020

Rutkowsky Jennifer M, Knotts Trina A, Allen Paul D, Pessah Isaac N, Ramsey Jon J

Abstract excerpt

Malignant hyperthermia (MH) is characterized by induction of skeletal muscle hyperthermia in response to a dysregulated increase in myoplasmic calcium. Although altered energetics play a central role in MH, MH-susceptible humans and mouse models are often described as having no phenotype until exposure to a triggering agent. The purpose of this study was to determine the influence of the R163C ryanodine receptor...

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Identifiers

PMID: 32367593
DOI: 10.1096/fj.202000403
PMCID: PMC7383697

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